The second weekend of historic local band lineups in WMBR’s Pipeline! 25^th anniversary series takes over Cuisine en Locale for two nights. Friday features early U2 opener Someone + the Somebodies’ first show in 30 years (on a Friday bill also including Nisi Period and Mistle Thrush) while Saturday’s ’90s-slanted slate offers the first Dirt Merchants show in 17 years, plus the Gravel Pit and the Sheila Divine. Last weekend’s long-lost reunions ranged from ’60s psychedelic band Freeborne to ’80s hardcore band Stranglehold, and they didn’t disappoint. Here’s the latest rundown to click for all the bands and set times.

It’s a busy weekend all over with a bunch of mid-level shows. Sun Kil Moon, the indie-folk band project of singer/songwriter Mark Kozelek (formerly of Red House Painters), brings dark, haunting sounds to Somerville Theatre on Friday. Scottish pop artist Paolo Nutini returns to charm House of Blues, and psych-garage luminary Ty Segall rocks Great Scott the same night.

Grizzled troubadour Willie Nelson plays a 2 p.m. Saturday matinee out at Indian Ranch in Webster – I kinda doubt that Johnny Depp will sit in like he did when Nelson played in town earlier this summer, but you never know. What you can count on is Nelson opening with this chestnut. And music fans up for the longer drive to the northwestern corner of the state should consider the star-stacked FreshGrass festival at MassMOCA in North Adams. The event runs Friday through Sunday with such broad acoustic artists as the Carolina Chocolate Drops, newcomer Valerie June (who slayed at Newport Folk), Railroad Earth, Hurray for the Riff Raff, ex-Hothouse Flowers frontman Liam O Maolai and heavyweights David Grisman and Emmylou Harris. Here’s the entire lineup/info on FreshGrass.

In town, Saturday night ranges from cheeky British pop star Lily Allen at House of Blues to Irish-American traditionalists Solas at the Somerville Theater, while across the street at Johnny D’s, Mike Peters from the Alarm translates his songs into acoustic declarations. And the biggest show of the weekend arrives Sunday with garage-rocking duo the Black Keys firing up their expanded sound at the TD Garden with opener Cage the Elephant.

Finally, for my Thursday Throwback, here’s the earliest known pro-shot video of an R.E.M. show from 1982, captured just after the release of the band’s debut Chronic Town EP and including tracks from the upcoming classic Murmur. So young and scruffy on Georgia cable TV.