HONK! if you love live music, especially if you love activist street bands taking it to the people at Columbus Day weekend’s free annual HONK! festival, split between Davis Square and Harvard Square. They’ll be lots of horns, percussion and street spirit fueled by crowd participation, as seen here with the What Cheer? Brigade, coming back as one of 27 bands taking part this year. Here’s the full schedule, though it’s easy to wander and find a mob scene or a band on a hidden byway.

Friday’s big show is the return of Fleetwood Mac to TD Garden, this time sounding more whole with Christine McVie back in action with Lindsey Buckingham, Stevie Nicks, John McVie and Mick Fleetwood after her 16-year retirement. And over at the Paradise Rock Club the same night, Berklee-bred pop singer/songstress Betty Who takes another step on her quest for world domination behind the release of her debut full-length Take Me When You Go. Here’s one of Who’s live confections. Other Friday concert options include the Carolina Chocolate Drops’ Dom Flemons going solo at Club Passim and a Crash Safely fundraiser for the National MS Society at Jamaica Plain’s Midway Café with the feisty Petty Morals, Gymnasium and Tsunami of Sound among others.

This weekend also marks the finale of Pipeline! at 25 presents: 50 Years of Boston Rock, a historic 13-night toast to the 25^th anniversary of MIT campus radio station WMBR. Cuisine en Locale gets busy on Friday with bands including Green Magnet School, Orbit and the Red Telephone, while Saturday brings the series’ hottest ticket to that Somerville hall with headliners the Cavedogs, Gigolo Aunts, Flying Nuns, Drumming on Glass, and the Dambuilders’ Dave Derby aboard. And the celebration spearheaded by former “Pipeline” host Bob Dubrow wraps on Sunday at the Middle East Downstairs with reunions by the Bags, Voodoo Dolls and the Underachievers. Here’s the full, final rundown (click on “see more” near the top).

Saturday also presents the opportunity to witness what ’60s psychedelia-shaded shenanigans that Foxygen can get itself into at the Paradise Rock Club. Another great Boston band from the past, Wheat, performs its 1997 lo-fi landmark Medeiros in its entirety at Atwood’s Tavern on Saturday, while Sunday offers the chance to catch broad-minded punk bassist Mike Watt ( the Minutemen, Stooges) in his experimental trio collaboration with Italy’s Il Sogno del Marinaio at Great Scott.