St. Patrick’s Day weekend’s here, and you know what that means: Dropkick Murphys fans are shipping out to House of Blues in droves for the local Celtic-punk heroes’ annual bash on Friday, Saturday (with a matinee as well as a late show that boasts both an acoustic performance and pro boxing live stream) and Sunday.

Yet there are so many other things happening, even on Friday alone, with local connections. I’m With Her (pictured)—an all-star Americana trio that features singer/instrumentalists Sara Watkins, NEC grad Sarah Jarosz and Newton-born Aofie O’Donovan—stands poised to captivate Sanders Theatre. Psych-pop rockers MGMT (formed at Connecticut’s Wesleyan University) expand horizons at the Orpheum Theatre. Lauded indie-rock outfit Palehound, led by singer/guitarist Ellen Kempner, roars at the Sinclair. And Berklee-schooled, unabashed pop star Betty Who brings her cheeky song and dance to the Brighton Music Hall.

Oregon-based Americana rockers Fruition also roll east into Somerville’s Once Ballroom on Friday, while Minneapolis-rooted, boundary-pushing piano trio the Bad Plus opens its next chapter at Scullers Jazz Club on Friday and Saturday with Orrin Evans joining bassist Reid Anderson and drummer Dave King in place of the departed Ethan Iverson.

Sunday also offers a particularly busy slate. The Chieftains—still led by Paddy Moloney on the tin whistle and Uilleann pipes—bring the Celtic holiday spirit to Lynn Auditorium, and award-winning country singer Lee Ann Womack graces City Winery. The acclaimed jazz saxophonist Rudresh Mahanthappa mashes cross-cultural genres with Indo-Pak Coalition in a World Music/CRASHarts concert at the ICA, while the unorthodox German composer/producer Nils Frahm hits the Sinclair on Sunday, his first of two nights merging classical and electronic territory with his bank of synthesizers and pianos. And speaking of mash-ups, Southern fusion-rockers the Dixie Dregs reunite their original lineup at the Tupelo Music Hall in Derry, N.H., on Sunday before hitting Boston to play the Wilbur on Monday. Here’s a jump to my recent interview with Dregs guitarist Steve Morse.