That locally bred, Brooklyn-based duo of ironic indie-pop They Might Be Giants hit House of Blues with their band on Friday behind I Like Fun, a new album balancing gloom and giddiness the way that guitarist John Flansburgh and keyboardist John Linnell like it. The same night, onetime local soul singer Amy Black returns to toast the music of Memphis and Muscle Shoals at Rockport’s Shalin Liu Performance Center (and Fall River’s Narrows Center for the Arts on Sunday). And Friday brings English prog-rock godsend Steven Wilson to the Berklee Performance Center in support of his new ’80s-influenced album To the Bone, backed by his sparkplug band including bassist Nick Beggs (Steve Hackett, Kajagoogoo). Here’s a jump to my recent interview with Wilson.

Saturday finds the revival of Seattle grunge stalwarts Alice in Chains (with decade-plus new singer William DuVall joining guitarist/songwriter Jerry Cantrell and the crew) at House of Blues, and ex-Joy Division/New Order bassist Peter Hook & the Light plays the Paradise Rock Club — with Hook playing guitar while his son Jack Bates handle the bass on many of those old classics. Platinum Colombian artist Juanes also serenades the Orpheum Theatre on Saturday, while Boston-based Irish singer/guitarist Christian McNeill trades his recent Hybrasil reunion for a night with the guest-laced Sea Monsters at Atwood’s Tavern. His Sea Monsters’ punchy soul burner “Zero” was one of the best Boston songs in the past decade.

Lexington gets extra concert cred this weekend, hosting Chicago-bred creative jazz pianist Myra Melford at the Follen Community Church on Saturday and a double bill of former Lovin’ Spoonful frontman John Sebastian and New Hampshire folk icon Tom Rush on Sunday. Also on Sunday, cellist Melora Creager (who toured with Nirvana) brings her steampunk-preceding outfit Rasputina to Brighton Music Hall.